TP53BP2

Across TCGA patient cohorts, TP53BP2 mutation is significantly associated with the RNA expression of many other genes, with 3,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53BP2-associated genes across cancer lineages are VARS2, YWHAE, and GMDS. Each is linked with TP53BP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TP53BP2-to-partner and partner-to-TP53BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VARS2 grouped by TP53BP2-low versus TP53BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP2→partner) and Y-score (partner→TP53BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VARS2 →	+0.274	+2.055	.004	<.001	3	4
SKCM	YWHAE →	+0.480	+2.446	.001	.001	3	3
UCEC	GMDS →	+0.509	+1.538	<.001	.002	3	3
SKCM	DAP →	+0.614	+2.700	.001	.006	3	3
SKCM	RPA1 →	+0.500	+2.729	.001	.003	3	3
SKCM	COX15 →	+0.527	+3.719	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,015 associations by consensus.

VARS2 by TP53BP2 expression — UCEC

Explore this box plot interactively →