TP53BP2

Across TCGA patient cohorts, TP53BP2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53BP2-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and eIF4E. Each is linked with TP53BP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TP53BP2-to-partner and partner-to-TP53BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TP53BP2-low versus TP53BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP2→partner) and Y-score (partner→TP53BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.264	+2.199	.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.202	-1.584	.007	.002	3	2
SKCM	eIF4E →	+0.294	+3.459	<.001	.005	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.410	+1.378	.006	.008	3	2
UCEC	Notch1 →	+0.150	+1.672	<.001	.006	3	2
SKCM	p70-S6K_pT389 →	-0.157	-3.000	.039	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

4E-BP1 by TP53BP2 expression — UCEC

Explore this box plot interactively →