TP53BP2

Across TCGA cell cohorts, TP53BP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,553 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TP53BP2-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Heterochromatin formation, and Negative regulation of gene expression, epigenetic. Each is linked with TP53BP2 in more than 15 cancer types. Because this analysis shows association rather than direction, both TP53BP2-to-partner and partner-to-TP53BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by TP53BP2-low versus TP53BP2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP2→partner) and Y-score (partner→TP53BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Epigenetic regulation of gene expression →	+0.075	+1.137	<.001	.001	3	16
STOMACH	Heterochromatin formation →	+0.069	+0.925	<.001	.001	3	14
STOMACH	Negative regulation of gene expression, epigenetic →	+0.085	+0.990	<.001	.004	3	14
STOMACH	Heterochromatin organization →	+0.066	+0.867	<.001	.003	3	14
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.131	+0.837	.002	.005	2	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair via homologous recombination →	+0.073	+0.931	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,553 associations by consensus.

Epigenetic regulation of gene expression by TP53BP2 expression — STOMACH

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