TP53BP2

Across TCGA cell cohorts, TP53BP2 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TP53BP2-associated genes across cancer lineages are HINT1, SLC5A8, and KRTAP4-2. Each is linked with TP53BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53BP2-to-partner and partner-to-TP53BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HINT1 grouped by TP53BP2-low versus TP53BP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53BP2→partner) and Y-score (partner→TP53BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HINT1 →	+0.459	+2.584	<.001	.002	3	2
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	1
OVARY	KRTAP4-2 →	+0.035	+5.196	<.001	.005	3	1
OVARY	MTRNR2L10 →	+0.006	+5.196	<.001	.005	3	1
STOMACH	GPR171 →	+0.034	+4.129	<.001	.007	3	1
LARGE_INTESTINE	GCAT →	+1.301	+2.743	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

HINT1 by TP53BP2 expression — LARGE_INTESTINE

Explore this box plot interactively →