TP53BP1

Across TCGA pan-cancer cohorts, TP53BP1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TP53BP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TP53BP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TP53BP1 is over-expressed in tumor.

COAD, LSCC, and LUAD are the cancer types where TP53BP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TP53BP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.302	<.001	12	view →
LSCC	Female	III,IV	+0.460	<.001	9	view →
LUAD	Male	III,IV	+0.515	<.001	8	view →
HNSC	Male	IV	+0.312	<.001	8	view →
CCRCC	Male	All	+0.099	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TP53BP1–COAD

Open the COAD breakdown →