TP53AIP1

Across TCGA patient cohorts, TP53AIP1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TP53AIP1-associated genes across cancer lineages are FoxM1, JNK_pT183_Y185, and Notch1. Each is linked with TP53AIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TP53AIP1-to-partner and partner-to-TP53AIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TP53AIP1-low versus TP53AIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TP53AIP1→partner) and Y-score (partner→TP53AIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.485	+2.817	.001	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.237	-2.986	.015	.037	3	1
UCEC	Notch1 →	+0.210	+3.000	.010	.037	3	1
UCEC	N-Ras →	-0.177	-2.986	.010	.037	3	1
UCEC	STAT3_pY705 →	-0.535	-3.000	<.001	.037	3	1
UCEC	PDCD4 →	-0.623	-3.000	.022	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FoxM1 by TP53AIP1 expression — UCEC

Explore this box plot interactively →