TP53

Across TCGA pan-cancer cohorts, TP53 Mutation is linked to patient survival in 17 of 34 cancer types, making it a survival-associated TP53 data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TP53 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TP53 expression acts as an unfavorable survival marker, although some lineages such as LUSC and MESO show a favorable association.

THYM, KIRP, and ACC are the cancer types where TP53 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.158	1.000	<.001	60	view →
KIRP	DFS	Median	All	0.417	0.923	<.001	36	view →
ACC	OS	Median	All	0.507	0.845	<.001	30	view →
KIRC	DFS	Median	All	0.174	0.634	<.001	27	view →
KICH	DFS	Median	II,III,IV	0.496	0.951	.002	24	view →
PAAD	DFS	Median	All	0.347	0.533	.001	21	view →
LAML	DFS	Median	All	0.102	0.592	<.001	18	view →
LUSC	OS	Median	All	0.709	0.606	.007	17	view →
LIHC	OS	Median	III,IV	0.465	0.709	.003	17	view →
HNSC	OS	Median	All	0.638	0.794	.003	16	view →
COAD	OS	Median	All	0.802	0.917	.002	14	view →
UCEC	DFS	Median	All	0.454	0.749	<.001	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TP53–THYM (OS)

Open the THYM breakdown →