TP53

Across TCGA pan-cancer cohorts, TP53 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TP53 data layer compared with 20 for mass-spec protein and 17 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TP53 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TP53 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, GBM, and LUAD are the cancer types where TP53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.935	0.499	.010	18	view →
GBM	OS	Quartile	All	0.532	0.275	.030	4	view →
LUAD	OS	Tertile	All	0.716	0.970	.003	4	view →
LSCC	OS	Quartile	II,III,IV	0.734	0.944	.038	2	view →
PDAC	OS	Tertile	II,III,IV	0.681	0.359	.025	2	view →
HNSC	DFS	Tertile	III,IV	0.500	0.746	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TP53–UCEC (DFS)

Open the UCEC breakdown →