TOX3

Across TCGA patient cohorts, TOX3 protein abundance is significantly associated with the RNA expression of many other genes, with 998 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TOX3-associated genes across cancer lineages are IL32, ARFGAP1, and OTX1. Each is linked with TOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOX3-to-partner and partner-to-TOX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOX3 versus IL32 in BRCA, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX3→partner) and Y-score (partner→TOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL32 →	-1.064	-0.800	.006	.007	3	2
LUAD	ARFGAP1 →	-0.781	-1.134	.003	<.001	3	1
LUAD	OTX1 →	-0.596	-0.823	.009	.009	3	1
LUAD	ZNHIT6 →	+0.833	+0.966	<.001	<.001	3	1
LUAD	ARMCX5 →	+0.443	+0.842	.009	<.001	3	1
LUAD	RPAIN →	+0.560	+0.875	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 998 associations by consensus.

TOX3 vs IL32 — BRCA

Explore this scatter interactively →