TOX3

Across TCGA patient cohorts, TOX3 mutation is significantly associated with the RNA expression of many other genes, with 4,348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOX3-associated genes across cancer lineages are TP53TG3, SNHG30, and SH3GL1P2. Each is linked with TOX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOX3-to-partner and partner-to-TOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53TG3 grouped by TOX3-low versus TOX3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX3→partner) and Y-score (partner→TOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TP53TG3 →	+0.048	+5.411	<.001	.005	3	3
UCEC	SNHG30 →	+0.428	+2.078	<.001	<.001	3	3
SKCM	SH3GL1P2 →	+0.257	+2.839	.004	.001	3	2
UCEC	TAF9 →	+0.607	+2.115	<.001	<.001	3	2
UCEC	ZNF2 →	+0.277	+2.475	.001	<.001	3	2
UCEC	WNT6 →	-0.831	-2.145	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,348 associations by consensus.

TP53TG3 by TOX3 expression — BLCA

Explore this box plot interactively →