TOX3

Across TCGA patient cohorts, TOX3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOX3-associated genes across cancer lineages are eIF4E, INPP4B, and PCNA. Each is linked with TOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOX3-to-partner and partner-to-TOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TOX3-low versus TOX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX3→partner) and Y-score (partner→TOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.161	+1.925	.033	.005	3	2
UCEC	INPP4B →	-0.306	-3.584	.008	.002	3	2
UCEC	PCNA →	+0.254	+2.906	.001	.001	3	2
UCEC	Rab11 →	-0.146	-2.321	.005	.001	3	2
UCEC	Annexin-1 →	+0.474	+2.000	.012	.029	3	2
UCEC	cIAP →	+0.115	+1.952	.020	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4E by TOX3 expression — UCEC

Explore this box plot interactively →