TOX3

Across TCGA cell cohorts, TOX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,568 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TOX3-associated GO terms across cancer lineages are Response to copper ion, Peptidyl-lysine oxidation, and Receptor-mediated endocytosis of virus by host cell. Each is linked with TOX3 in more than 10 cancer types. Because this analysis shows association rather than direction, both TOX3-to-partner and partner-to-TOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to copper ion grouped by TOX3-low versus TOX3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX3→partner) and Y-score (partner→TOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to copper ion →	-0.152	-1.945	<.001	.002	3	11
URINARY_TRACT	Peptidyl-lysine oxidation →	-1.138	-1.729	<.001	.009	3	10
LUNG_NSCLC_LUSC	Receptor-mediated endocytosis of virus by host cell →	-0.294	-2.702	<.001	<.001	3	10
STOMACH	Positive regulation of extrinsic apoptotic signaling pathway →	-0.142	-1.977	<.001	<.001	3	9
STOMACH	Detoxification of copper ion →	-0.300	-1.837	<.001	.001	3	9
STOMACH	Stress response to copper ion →	-0.300	-1.837	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,568 associations by consensus.

Response to copper ion by TOX3 expression — LUNG_NSCLC_LUSC

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