TOX3

Across TCGA cell cohorts, TOX3 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOX3-associated genes across cancer lineages are SIGLEC7, IQCA1L, and C20orf85. Each is linked with TOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOX3-to-partner and partner-to-TOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC7 grouped by TOX3-low versus TOX3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX3→partner) and Y-score (partner→TOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC7 →	+0.039	+3.215	<.001	.007	3	2
LUNG_NSCLC_LUAD	IQCA1L →	+0.037	+3.882	.008	.003	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR51L1 →	+0.036	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

SIGLEC7 by TOX3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →