TOX2

Across TCGA patient cohorts, TOX2 mutation is significantly associated with the RNA expression of many other genes, with 2,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOX2-associated genes across cancer lineages are CCDC58P2, TIMM13, and RAD51. Each is linked with TOX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TOX2-to-partner and partner-to-TOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC58P2 grouped by TOX2-low versus TOX2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX2→partner) and Y-score (partner→TOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CCDC58P2 →	+0.160	+5.418	<.001	.005	3	4
SKCM	TIMM13 →	+0.361	+2.749	<.001	<.001	3	4
UCEC	RAD51 →	+0.767	+2.595	<.001	<.001	3	3
UCEC	TIPIN →	+0.488	+2.606	.001	<.001	3	3
UCEC	CDC34 →	+0.432	+3.609	.003	.001	3	3
BRCA	LINC00428 →	+0.076	+4.121	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,512 associations by consensus.

CCDC58P2 by TOX2 expression — CESC

Explore this box plot interactively →