TOX2

Across TCGA patient cohorts, TOX2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOX2-associated genes across cancer lineages are 4E-BP1, eIF4E, and Heregulin. Each is linked with TOX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TOX2-to-partner and partner-to-TOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TOX2-low versus TOX2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX2→partner) and Y-score (partner→TOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	4E-BP1 →	+0.498	+3.009	.013	.019	3	4
UCEC	eIF4E →	+0.236	+3.013	.013	.018	3	3
SKCM	Heregulin →	+0.146	+1.874	.012	.047	3	2
SKCM	CDK1_pY15 →	+0.242	+3.169	.046	.017	3	2
SKCM	CDK1 →	+0.174	+1.514	.003	.014	3	2
UCEC	p62 Lck ligand →	+0.555	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

4E-BP1 by TOX2 expression — LUSC

Explore this box plot interactively →