TOX2

Across TCGA cell cohorts, TOX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,612 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TOX2-associated GO terms across cancer lineages are T cell differentiation in thymus, Regulation of fibroblast proliferation, and Pyrimidine-containing compound transmembrane transport. Each is linked with TOX2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TOX2-to-partner and partner-to-TOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T cell differentiation in thymus grouped by TOX2-low versus TOX2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX2→partner) and Y-score (partner→TOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	T cell differentiation in thymus →	+0.098	+1.654	<.001	<.001	3	9
BREAST	Regulation of fibroblast proliferation →	+0.108	+2.326	<.001	<.001	3	9
SOFT_TISSUE	Pyrimidine-containing compound transmembrane transport →	-0.117	-2.091	<.001	<.001	3	9
SKIN	Regulation of intracellular transport →	+0.061	+1.990	<.001	<.001	3	9
BREAST	Negative regulation of interleukin-1 beta production →	+0.140	+1.560	<.001	<.001	3	9
BREAST	Epiboly involved in wound healing →	+0.152	+2.121	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,612 associations by consensus.

T cell differentiation in thymus by TOX2 expression — BREAST

Explore this box plot interactively →