TOX2

Across TCGA cell cohorts, TOX2 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TOX2-associated genes across cancer lineages are PPIAL4E, CST8, and METTL21C. Each is linked with TOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOX2-to-partner and partner-to-TOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4E grouped by TOX2-low versus TOX2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX2→partner) and Y-score (partner→TOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPIAL4E →	+0.027	+4.643	<.001	.004	3	1
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	METTL21C →	+0.155	+4.273	<.001	.006	3	1
LARGE_INTESTINE	FAM71B →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR2K2 →	+0.037	+4.095	<.001	.009	3	1
LARGE_INTESTINE	VCX2 →	+1.507	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PPIAL4E by TOX2 expression — LUNG_SCLC

Explore this box plot interactively →