Across TCGA patient cohorts, TOX protein abundance is significantly associated with the RNA expression of many other genes, with 2,302 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TOX-associated genes across cancer lineages are CYTH4, IFFO1, and STAB1. Each is linked with TOX in more than 1 cancer types. Because this analysis shows association rather than direction, both TOX-to-partner and partner-to-TOX results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX→partner) and Y-score (partner→TOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYTH4 →	+1.122	+0.709	.003	<.001	3	2
LSCC	IFFO1 →	+0.814	+0.717	.001	.005	3	2
UCEC	STAB1 →	+1.067	+0.497	.001	.002	3	2
LSCC	CEACAM4 →	+0.733	+0.448	.003	.005	3	2
UCEC	CD33 →	+0.662	+0.664	.002	.001	3	2
LSCC	SIGLEC6 →	+0.719	+0.855	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,302 associations by consensus.

Exploration

TOX survival (RNA) · tumor vs normal (RNA) · all TOX data types