Across TCGA patient cohorts, TOX mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOX-associated genes across cancer lineages are TFRC, Cyclin-B1, and FoxM1. Each is linked with TOX in more than 2 cancer types. Because this analysis shows association rather than direction, both TOX-to-partner and partner-to-TOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX→partner) and Y-score (partner→TOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.464	+1.473	.004	.006	3	3
UCEC	Cyclin-B1 →	+0.581	+2.415	<.001	.002	3	3
UCEC	FoxM1 →	+0.182	+1.473	.021	.006	3	2
UCEC	GAPDH →	+0.358	+1.502	.029	.027	3	2
UCEC	MEK1 →	+0.431	+2.222	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.483	+1.867	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

TOX survival (RNA) · tumor vs normal (RNA) · all TOX data types