Across TCGA cell cohorts, TOX mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOX-associated genes across cancer lineages are OR13D1, PRKACG, and H2BC1. Each is linked with TOX in more than 2 cancer types. Because this analysis shows association rather than direction, both TOX-to-partner and partner-to-TOX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOX→partner) and Y-score (partner→TOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR13D1 →	+0.016	+3.977	<.001	.007	3	3
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	2
SOFT_TISSUE	H2BC1 →	+0.216	+3.977	<.001	.007	3	1
SOFT_TISSUE	H2AC1 →	+0.096	+3.977	<.001	.007	3	1
SOFT_TISSUE	GAGE12E →	+0.061	+3.930	<.001	.001	3	1
SOFT_TISSUE	CT45A8 →	+1.004	+3.459	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

TOX survival (RNA) · tumor vs normal (RNA) · all TOX data types