Across TCGA cell cohorts, TOR3A mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOR3A-associated genes across cancer lineages are OR11H1, OR4K2, and PRORY. Each is linked with TOR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR3A-to-partner and partner-to-TOR3A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR3A→partner) and Y-score (partner→TOR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H1 →	+0.097	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4K2 →	+0.042	+5.969	<.001	.001	3	1
BLOOD_Leukemia	PRORY →	+0.173	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR11G2 →	+0.392	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.024	+6.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TOR3A survival (RNA) · tumor vs normal (RNA) · all TOR3A data types