TOR1B

Across TCGA patient cohorts, TOR1B mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR1B-associated genes across cancer lineages are N-Ras, EGFR_pY1068, and A-Raf_pS299. Each is linked with TOR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR1B-to-partner and partner-to-TOR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Ras grouped by TOR1B-low versus TOR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR1B→partner) and Y-score (partner→TOR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Ras →	-0.113	-1.986	.035	.032	3	2
UCEC	EGFR_pY1068 →	-0.321	-2.700	.004	.006	3	1
UCEC	A-Raf_pS299 →	-0.177	-2.321	<.001	.034	3	1
UCEC	FoxM1 →	+0.280	+2.000	.016	.032	3	1
UCEC	FOXO3a_pS318_S321 →	-0.123	-3.160	.028	.019	3	1
UCEC	ACVRL1 →	-0.126	-2.302	.039	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

N-Ras by TOR1B expression — UCEC

Explore this box plot interactively →