TOR1AIP2

Across TCGA patient cohorts, TOR1AIP2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR1AIP2-associated genes across cancer lineages are c-Kit, JNK_pT183_Y185, and MSH2. Each is linked with TOR1AIP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOR1AIP2-to-partner and partner-to-TOR1AIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by TOR1AIP2-low versus TOR1AIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR1AIP2→partner) and Y-score (partner→TOR1AIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.201	-1.906	.032	.016	3	3
UCEC	JNK_pT183_Y185 →	-0.138	-2.321	.042	.034	3	1
UCEC	MSH2 →	-0.255	-1.990	.006	.030	3	1
UCEC	p27_pT198 →	+0.099	+2.415	.021	.003	3	1
UCEC	p62 Lck ligand →	+0.425	+3.331	.001	.005	3	1
UCEC	Rictor_pT1135 →	-0.082	-1.906	.045	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

c-Kit by TOR1AIP2 expression — UCEC

Explore this box plot interactively →