TOR1AIP1

Across TCGA patient cohorts, TOR1AIP1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOR1AIP1-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and Rad50. Each is linked with TOR1AIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOR1AIP1-to-partner and partner-to-TOR1AIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TOR1AIP1-low versus TOR1AIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOR1AIP1→partner) and Y-score (partner→TOR1AIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.172	+3.183	.038	.009	3	2
UCEC	p62 Lck ligand →	+0.292	+2.502	.022	.002	3	2
UCEC	Rad50 →	-0.221	-2.502	.020	.002	3	2
UCEC	EGFR_pY1068 →	-0.242	-3.169	.014	.018	3	1
UCEC	ERK2 →	+0.199	+2.222	.008	.010	3	1
UCEC	HER3 →	-0.219	-1.571	.042	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by TOR1AIP1 expression — UCEC

Explore this box plot interactively →