Across TCGA patient cohorts, TOPORS protein abundance is significantly associated with the RNA expression of many other genes, with 2,879 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TOPORS-associated genes across cancer lineages are PGPEP1, ABCD2, and LINC01839. Each is linked with TOPORS in more than 1 cancer types. Because this analysis shows association rather than direction, both TOPORS-to-partner and partner-to-TOPORS results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORS→partner) and Y-score (partner→TOPORS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PGPEP1 →	-0.712	-0.517	.003	.003	3	2
GBM	ABCD2 →	-0.709	-0.426	.004	.002	3	2
HNSC	LINC01839 →	-0.213	-0.493	<.001	.002	3	2
PDAC	SETP9 →	-0.476	-0.836	.002	.005	3	2
HNSC	STAP1 →	-0.838	-0.633	.008	.004	3	2
LSCC	EEF1AKNMT →	+0.386	+0.198	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,879 associations by consensus.

Exploration

TOPORS survival (RNA) · tumor vs normal (RNA) · all TOPORS data types