Across TCGA patient cohorts, TOPORS mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOPORS-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and eIF4E. Each is linked with TOPORS in more than 2 cancer types. Because this analysis shows association rather than direction, both TOPORS-to-partner and partner-to-TOPORS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORS→partner) and Y-score (partner→TOPORS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.635	+1.671	<.001	.003	3	3
LUSC	MSH2 →	+0.361	+3.179	.018	.010	3	2
UCEC	eIF4E →	+0.170	+1.906	.005	<.001	3	2
UCEC	JNK2 →	+0.215	+1.485	<.001	.003	3	2
UCEC	Notch1 →	+0.152	+2.083	<.001	<.001	3	2
LUSC	p27_pT157 →	+0.103	+2.834	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

TOPORS survival (RNA) · tumor vs normal (RNA) · all TOPORS data types