Across TCGA cell cohorts, TOPORS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,412 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOPORS-associated GO terms across cancer lineages are Protein monoubiquitination, Protein localization to nucleus, and Protein sumoylation. Each is linked with TOPORS in more than 14 cancer types. Because this analysis shows association rather than direction, both TOPORS-to-partner and partner-to-TOPORS results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORS→partner) and Y-score (partner→TOPORS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein monoubiquitination →	+0.089	+0.617	.003	.007	3	15
OESOPHAGUS	Protein localization to nucleus →	+0.063	+0.771	.001	.001	3	13
STOMACH	Protein sumoylation →	+0.090	+0.587	.002	.008	2	13
STOMACH	Regulation of organelle assembly →	+0.061	+0.736	.003	.001	3	12
LUNG_SCLC	Centriole-centriole cohesion →	+0.115	+0.700	<.001	<.001	3	11
SOFT_TISSUE	Regulation of cytokinesis →	+0.078	+0.694	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,412 associations by consensus.

Exploration

TOPORS survival (RNA) · tumor vs normal (RNA) · all TOPORS data types