Across TCGA cell cohorts, TOPORS mutation is significantly associated with the RNA expression of many other genes, with 472 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOPORS-associated genes across cancer lineages are CFHR2, LYPD4, and KRT73. Each is linked with TOPORS in more than 1 cancer types. Because this analysis shows association rather than direction, both TOPORS-to-partner and partner-to-TOPORS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORS→partner) and Y-score (partner→TOPORS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	2
BLOOD_Lymphoma	LYPD4 →	+0.118	+4.867	<.001	.009	3	2
LUNG_NSCLC_LUAD	KRT73 →	+0.062	+3.215	<.001	.007	3	1
BLOOD_Leukemia	APCS →	+0.128	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 472 associations by consensus.

Exploration

TOPORS survival (RNA) · tumor vs normal (RNA) · all TOPORS data types