Across TCGA cell cohorts, TOPORS mutation is significantly associated with the mutation status of many other genes, with 6,313 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOPORS-associated genes across cancer lineages are ASB11, PLCL1, and CPSF7. Each is linked with TOPORS in more than 3 cancer types. Because this analysis shows association rather than direction, both TOPORS-to-partner and partner-to-TOPORS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPORS→partner) and Y-score (partner→TOPORS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB11 →	+4.894	+4.894	.004	.004	1	4
BLOOD_Lymphoma	PLCL1 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	CPSF7 →	+5.014	+5.584	.003	.003	1	4
BLOOD_Lymphoma	DNAAF1 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	MARCHF3 →	+6.014	+6.014	.001	.001	1	4
BLOOD_Lymphoma	MED14 →	+4.014	+4.969	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,313 associations by consensus.

Exploration

TOPORS survival (RNA) · tumor vs normal (RNA) · all TOPORS data types