TOP3B

Across TCGA pan-cancer cohorts, TOP3B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TOP3B data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TOP3B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TOP3B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where TOP3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	1.000	0.512	.002	29	view →
HNSC	OS	Quartile	All	0.589	0.853	.006	13	view →
LUAD	OS	Median	All	0.988	0.934	.018	7	view →
GBM	OS	Tertile	All	0.670	0.263	<.001	6	view →
PDAC	OS	Tertile	III,IV	1.000	0.459	.013	6	view →
LSCC	OS	Quartile	III,IV	0.733	0.972	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TOP3B–CCRCC (OS)

Open the CCRCC breakdown →