TOP3B

Across TCGA pan-cancer cohorts, TOP3B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TOP3B’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TOP3B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TOP3B is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

PDAC, CCRCC, and LUAD are the cancer types where TOP3B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOP3B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.403	<.001	9	view →
CCRCC	Male	III,IV	−0.091	.002	7	view →
LUAD	Female	III,IV	−0.210	<.001	6	view →
HNSC	Male	II,III,IV	−0.109	<.001	6	view →
LSCC	Male	II,III,IV	+0.166	<.001	5	view →
COAD	Female	II,III,IV	−0.186	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TOP3B–PDAC

Open the PDAC breakdown →