TOP3B

Across TCGA patient cohorts, TOP3B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP3B-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with TOP3B in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP3B-to-partner and partner-to-TOP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TOP3B-low versus TOP3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3B→partner) and Y-score (partner→TOP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.217	-1.584	.005	.005	3	2
UCEC	eIF4E →	+0.170	+2.335	.010	.002	3	2
UCEC	ERK2 →	+0.161	+2.321	.008	.005	3	2
UCEC	MEK1 →	+0.537	+2.807	<.001	<.001	3	2
UCEC	ATM →	-0.506	-2.074	<.001	.004	3	2
UCEC	Caspase-7-cleavedD198 →	+0.579	+1.434	.001	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by TOP3B expression — UCEC

Explore this box plot interactively →