TOP3B

Across TCGA cell cohorts, TOP3B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,882 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TOP3B-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and DNA topological change. Each is linked with TOP3B in more than 19 cancer types. Because this analysis shows association rather than direction, both TOP3B-to-partner and partner-to-TOP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by TOP3B-low versus TOP3B-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3B→partner) and Y-score (partner→TOP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Symbiont-mediated disruption of host cellular anatomical structure →	+0.224	+1.318	<.001	<.001	3	20
BREAST	Symbiont-mediated disruption of host anatomical structure →	+0.224	+1.318	<.001	<.001	3	20
LUNG_SCLC	DNA topological change →	+0.143	+0.770	<.001	<.001	3	19
BONE	Subtelomeric heterochromatin formation →	+0.187	+1.162	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.077	+1.111	<.001	<.001	3	17
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.175	+0.914	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,882 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by TOP3B expression — BREAST

Explore this box plot interactively →