TOP3A

Across TCGA pan-cancer cohorts, TOP3A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TOP3A data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TOP3A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TOP3A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where TOP3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.931	0.446	<.001	37	view →
HNSC	OS	Quartile	All	0.727	0.899	.014	27	view →
LUAD	DFS	Median	III,IV	0.984	0.536	<.001	16	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.389	.042	4	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.337	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TOP3A–LSCC (OS)

Open the LSCC breakdown →