TOP3A

Across TCGA pan-cancer cohorts, TOP3A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TOP3A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TOP3A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TOP3A is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

HNSC, LSCC, and PDAC are the cancer types where TOP3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOP3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.497	<.001	8	view →
LSCC	Female	All	+0.495	<.001	8	view →
PDAC	All	All	+0.359	.004	5	view →
CCRCC	Male	All	−0.068	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TOP3A–HNSC

Open the HNSC breakdown →