TOP3A

Across TCGA cell cohorts, TOP3A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,230 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP3A-associated GO terms across cancer lineages are Regulation of DNA repair, Microtubule polymerization or depolymerization, and Telomere organization. Each is linked with TOP3A in more than 17 cancer types. Because this analysis shows association rather than direction, both TOP3A-to-partner and partner-to-TOP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by TOP3A-low versus TOP3A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3A→partner) and Y-score (partner→TOP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.070	+1.235	<.001	<.001	3	18
BONE	Microtubule polymerization or depolymerization →	+0.109	+0.927	.003	.002	3	17
UPPER_AERODIGESTIVE_TRACT	Telomere organization →	+0.106	+1.268	<.001	<.001	3	17
URINARY_TRACT	Microtubule polymerization →	+0.127	+1.321	<.001	<.001	3	17
BONE	Regulation of RNA export from nucleus →	+0.132	+0.910	<.001	.004	3	17
LUNG_NSCLC_LUSC	Positive regulation of DNA metabolic process →	+0.063	+1.147	.006	.004	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,230 associations by consensus.

Regulation of DNA repair by TOP3A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →