TOP3A

Across TCGA cell cohorts, TOP3A mutation is significantly associated with the RNA expression of many other genes, with 618 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP3A-associated genes across cancer lineages are OR56A4, NOBOX, and PF4V1. Each is linked with TOP3A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP3A-to-partner and partner-to-TOP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A4 grouped by TOP3A-low versus TOP3A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3A→partner) and Y-score (partner→TOP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR56A4 →	+0.013	+5.614	<.001	.002	3	2
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	PF4V1 →	+0.296	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	OR4F5 →	+0.063	+4.643	.001	.008	3	2
BLOOD_Lymphoma	HTR3D →	+0.015	+5.247	<.001	.001	3	2
LARGE_INTESTINE	SLC25A11 →	+0.819	+3.212	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 618 associations by consensus.

OR56A4 by TOP3A expression — PANCREAS

Explore this box plot interactively →