TOP3A

Across TCGA cell cohorts, TOP3A mutation is significantly associated with the mutation status of many other genes, with 5,414 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOP3A-associated genes across cancer lineages are MN1, SCN5A, and PRRC2A. Each is linked with TOP3A in more than 5 cancer types. Because this analysis shows association rather than direction, both TOP3A-to-partner and partner-to-TOP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MN1 grouped by TOP3A-low versus TOP3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP3A→partner) and Y-score (partner→TOP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MN1 →	+2.491	+3.278	<.001	<.001	1	6
BLOOD_Leukemia	SCN5A →	+2.847	+2.768	<.001	<.001	1	5
BLOOD_Leukemia	PRRC2A →	+2.655	+2.655	<.001	<.001	1	5
BLOOD_Leukemia	CHD7 →	+2.195	+2.351	.001	.001	1	5
LUNG_SCLC	ARHGEF26 →	+4.502	+5.066	.007	.007	1	5
LARGE_INTESTINE	ANKS1A →	+4.129	+3.292	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,414 associations by consensus.

MN1 by TOP3A expression — LARGE_INTESTINE

Explore this box plot interactively →