TOP2B

Across TCGA pan-cancer cohorts, TOP2B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TOP2B data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TOP2B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TOP2B expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where TOP2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.441	1.000	.020	10	view →
HNSC	OS	Tertile	All	0.594	0.824	.007	9	view →
LSCC	OS	Median	II,III,IV	0.890	0.618	.015	4	view →
PDAC	DFS	Quartile	All	0.863	0.806	.033	3	view →
LUAD	DFS	Tertile	All	0.729	0.463	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TOP2B–UCEC (DFS)

Open the UCEC breakdown →