TOP2B

Across TCGA patient cohorts, TOP2B mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP2B-associated genes across cancer lineages are PKC-b-II_pS660, TFRC, and TSC1. Each is linked with TOP2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP2B-to-partner and partner-to-TOP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by TOP2B-low versus TOP2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP2B→partner) and Y-score (partner→TOP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.446	-3.000	.003	.034	3	2
COAD	TFRC →	+0.754	+3.033	.001	.017	3	2
COAD	TSC1 →	-0.384	-2.450	.001	.020	3	2
UCEC	INPP4B →	-0.198	-1.514	.039	.012	3	2
UCEC	JNK_pT183_Y185 →	-0.129	-1.584	.010	.017	3	2
UCEC	MEK1 →	+0.425	+2.050	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PKC-b-II_pS660 by TOP2B expression — COAD

Explore this box plot interactively →