TOP2B

Across TCGA cell cohorts, TOP2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,783 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP2B-associated GO terms across cancer lineages are Positive regulation of DNA repair, Regulation of chromosome segregation, and Mitotic spindle assembly. Each is linked with TOP2B in more than 15 cancer types. Because this analysis shows association rather than direction, both TOP2B-to-partner and partner-to-TOP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by TOP2B-low versus TOP2B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP2B→partner) and Y-score (partner→TOP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.082	+1.473	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.124	+1.000	.002	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle assembly →	+0.105	+1.031	.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.093	+1.443	<.001	<.001	3	14
SOFT_TISSUE	Regulation of DNA repair →	+0.077	+0.888	<.001	<.001	3	14
OVARY	Transcription elongation by RNA polymerase II →	+0.104	+1.028	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,783 associations by consensus.

Positive regulation of DNA repair by TOP2B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →