TOP2B

Across TCGA cell cohorts, TOP2B mutation is significantly associated with the RNA expression of many other genes, with 477 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOP2B-associated genes across cancer lineages are GK2, OR4D1, and PRAMEF4. Each is linked with TOP2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP2B-to-partner and partner-to-TOP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GK2 grouped by TOP2B-low versus TOP2B-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP2B→partner) and Y-score (partner→TOP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GK2 →	+0.115	+4.736	<.001	.009	3	2
CNS	OR4D1 →	+0.050	+3.874	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF4 →	+0.186	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR2B3 →	+0.061	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 477 associations by consensus.

GK2 by TOP2B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →