Across TCGA pan-cancer cohorts, TOP1MT Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TOP1MT data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TOP1MT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TOP1MT expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and BLCA are the cancer types where TOP1MT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.141	0.904	<.001	36	view →
UCEC	OS	Median	II,III,IV	1.000	0.320	.008	32	view →
BLCA	DFS	Median	III,IV	0.175	0.549	.018	12	view →
SKCM	OS	Median	All	0.257	0.781	.015	9	view →
LUAD	DFS	Median	All	0.213	0.676	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TOP1MT tumor-vs-normal RNA expression · all TOP1MT data types