Across TCGA patient cohorts, TOP1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,479 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TOP1-associated genes across cancer lineages are CSE1L, PLSCR4, and CNRIP1. Each is linked with TOP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both TOP1-to-partner and partner-to-TOP1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1→partner) and Y-score (partner→TOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CSE1L →	+0.597	+0.378	<.001	<.001	3	9
BRCA	PLSCR4 →	-1.041	-0.331	<.001	<.001	3	8
UCEC	CNRIP1 →	-0.852	-0.288	<.001	<.001	3	8
UCEC	ABCA8 →	-1.155	-0.288	<.001	<.001	3	8
BRCA	ZEB1 →	-1.312	-0.464	<.001	<.001	3	8
BRCA	MSRB3 →	-1.523	-0.401	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,479 associations by consensus.

Exploration

TOP1 survival (RNA) · tumor vs normal (RNA) · all TOP1 data types