Across TCGA patient cohorts, TOP1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP1-associated genes across cancer lineages are PKC-delta_pS664, TFRC, and 14-3-3_beta. Each is linked with TOP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOP1-to-partner and partner-to-TOP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1→partner) and Y-score (partner→TOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.088	-2.160	.021	.003	3	3
UCEC	TFRC →	+0.449	+2.415	.008	.003	3	2
UCEC	14-3-3_beta →	-0.065	-1.880	.041	.014	3	1
UCEC	EGFR_pY1068 →	-0.165	-1.289	.039	.023	3	1
UCEC	eIF4E →	+0.133	+1.289	.049	.023	3	1
UCEC	eIF4G →	+0.224	+2.321	.023	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

TOP1 survival (RNA) · tumor vs normal (RNA) · all TOP1 data types