Across TCGA cell cohorts, TOP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,920 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TOP1-associated GO terms across cancer lineages are Transcription elongation by RNA polymerase II, Promoter clearance during DNA-templated transcription, and RNA polymerase II promoter clearance. Each is linked with TOP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both TOP1-to-partner and partner-to-TOP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1→partner) and Y-score (partner→TOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Transcription elongation by RNA polymerase II →	+0.081	+0.416	.002	.006	3	15
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.151	+1.065	<.001	.001	3	15
KIDNEY	RNA polymerase II promoter clearance →	+0.151	+1.065	<.001	.001	3	15
BONE	DNA-templated transcription initiation →	+0.093	+0.845	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase III →	+0.070	+0.889	.008	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.160	+1.011	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,920 associations by consensus.

Exploration

TOP1 survival (RNA) · tumor vs normal (RNA) · all TOP1 data types