Across TCGA cell cohorts, TOP1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOP1-associated genes across cancer lineages are CD300E, LRIT2, and TARM1. Each is linked with TOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP1-to-partner and partner-to-TOP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP1→partner) and Y-score (partner→TOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CD300E →	+0.032	+5.044	<.001	<.001	3	1
URINARY_TRACT	LRIT2 →	+0.027	+4.087	.001	.009	3	1
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
LARGE_INTESTINE	MDGA2 →	+0.134	+2.591	<.001	.008	3	1
LARGE_INTESTINE	ACER1 →	+0.111	+3.938	<.001	<.001	3	1
LARGE_INTESTINE	WDR87 →	+0.016	+2.716	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TOP1 survival (RNA) · tumor vs normal (RNA) · all TOP1 data types