TONSL

Across TCGA pan-cancer cohorts, TONSL mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TONSL’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TONSL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TONSL is over-expressed in tumor.

LSCC, LUAD, and HNSC are the cancer types where TONSL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TONSL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.629	<.001	8	view →
LUAD	Male	All	+0.336	<.001	8	view →
HNSC	Male	II,III,IV	+0.223	.003	8	view →
PDAC	All	All	+0.501	.002	4	view →
CCRCC	All	All	+0.179	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TONSL–LSCC

Open the LSCC breakdown →