TONSL

Across TCGA patient cohorts, TONSL mutation is significantly associated with the RNA expression of many other genes, with 2,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TONSL-associated genes across cancer lineages are OR5P4P, MIR4518, and GON7. Each is linked with TONSL in more than 2 cancer types. Because this analysis shows association rather than direction, both TONSL-to-partner and partner-to-TONSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5P4P grouped by TONSL-low versus TONSL-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TONSL→partner) and Y-score (partner→TONSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR5P4P →	+0.295	+4.320	<.001	.007	3	3
CESC	MIR4518 →	+0.408	+4.196	<.001	.003	3	3
UCEC	GON7 →	+0.473	+2.301	.004	.001	3	3
UCEC	TIMM21 →	+0.479	+2.747	.001	<.001	3	3
HNSC	CDY7P →	+0.030	+5.141	<.001	.001	3	3
HNSC	RNU4ATAC6P →	+0.591	+5.468	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,000 associations by consensus.

OR5P4P by TONSL expression — HNSC

Explore this box plot interactively →