TONSL

Across TCGA patient cohorts, TONSL mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TONSL-associated genes across cancer lineages are ATM, 14-3-3_beta, and eIF4E. Each is linked with TONSL in more than 1 cancer types. Because this analysis shows association rather than direction, both TONSL-to-partner and partner-to-TONSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TONSL-low versus TONSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TONSL→partner) and Y-score (partner→TONSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.560	-4.000	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.096	-2.973	.024	.035	3	1
UCEC	eIF4E →	+0.185	+2.820	.038	.035	3	1
UCEC	ERK2 →	+0.248	+2.906	.002	.001	3	1
UCEC	IGFBP2 →	-0.676	-2.222	.014	.011	3	1
UCEC	JNK2 →	+0.325	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by TONSL expression — UCEC

Explore this box plot interactively →